User experience with alternative databases in Mike Urban?

Was curious if anyone has been using some of the alternative databases for storing the model within Mike Urban and had any thoughts on the experience. Our GIS staff suggested we should see a pretty big performance jump moving from a personal geodatabase format to a file geodatabase; I also was curious about ArcSDE. I was particularly curious if there was much of an observable benefit (e.g., speed on clicking edit, speed switching scenarios), or losses of particular functionality (e.g., scenario manager).