Yes, the origin for 2D vertical models is quite important, because the head is based on a level over datum. In contrast, 3D models usually have implicitly this level in the input data. If you refer to sea level (0 m), I suggest to keep the origin at 0 m without any transformation or shifting. You simply need to assure that the y-coordinates (gravity axis) in the 2D Supermesh refer to elevations above sea level.