Hi,
this is probably a claccic issue with the classical (rectangular) grid version of MIKE 21: all boundaries must always be wet during the simulation, otherwise boundary conditions aren't applied.
So the issue is most likely that your initial condition is such that the boundary cells are initially dry / inactive, and the result is that the water won't flow from the upstream boundary. The solution is simply to edit the initial condition, and make sure that the boundary cells are initially wet.
Best regards,
Mathieu