Hi Jérémie,
a "Write error" could be due to a lack of free space on your harddisk, or to the fact that you save the result file on a network drive which is unavailable.
To reduce the Courant number, you have to either use coarser cells or reduce the simulation time step. The time step values you mention seem to be quite high, except if you use a very coarse resolution.
Where do you get the Courant number values from? Is this a result, or the informative value which is provided in the 'Simulation period' menu of MIKE 21? Note that the latter is only an approximation, since the actual Courant number will vary during the simulation, depending on water depths and velocities. And do you use a flexible mesh or a rectangular grid?
Best regards,
Mathieu