MIKE SHE is a flexible modelling framework that can model each hydrological process as well as combine the hydrological processes and numerical methods depending on the requirements of your application and data availability.
Thus there may be different approaches to get hydrograph results somewhere in your river basin (or the outlet) depending on each case study.
For instance you could couple MIKE SHE and MIKE HYDRO River to assess in more detail the dynamic interaction between the river model and MIKE SHE Overland/Groundwater components. Alternatively you could rely entirely in MIKE SHE, particularly the Overland flow component by applying either a Finite Difference or Subcatchment-based solution method and then use the MIKE SHE Water Balance Analysis tool to get hydrograph results for a sub-basin or the whole basin.
The minimum data requirements would probably include rainfall/reference evapotranspiration parameters, the DEM and a shapefile of your model domain. You could of course add as much data you have available (e.g. land uses, distributed soil/geology, irrigation, drainage network, abstractions, ..).
Hope this answers your question ( ? )