Hi Giacomo,
and apologies for the huge delay in replying to this.
I actually understood the error was at another stage of the process - which would suggest some error at the level of the block library, as I initially tried to explain.
However, what you are now reporting is much easier to solve - in fact not a real error ..
Basically, you have created a new Instance (with a new list of Components).
Clearly, a [b]Fractionation Layout[/b] will not be available for your new Instance - unless the Components are the same as one of the standard Instances, which I believe is not the case.
So, what you can do is indeed to load one of the Layouts (the one with the state vector closests to that of your new Instance); then you need to make the necessary changes and save the new Layout - that will then be available every time you'll use your new Instance.
The message you get may be a little unclear, and especially the outcome a little unexpected (we're working to improve this!), because [b]whether you answer 'yes' or 'no' you will lose some information[/b].
As I said: all you need to do is to modify the Layout according to your influent model and save it, so that it will be available for other projects.